nuclear antigens การใช้

• Pleomorphic pattern is caused by antibodies to the proliferating cell nuclear antigen.
• Primary biliary cirrhosis ( PBC ) is an autoimmune disease characterized by autoantibodies against mitochondrial and nuclear antigens.
• This process involves proliferating cell nuclear antigen, the single strand-binding protein replication protein A and NS1.
• These might include : rheumatoid factor, antinuclear factor ( ANF ), extractable nuclear antigen, and specific antibodies.
• In eukaryotes, the sliding clamp is a homotrimer ring structure known as the proliferating cell nuclear antigen ( PCNA ).
• These include the four key proteins involved in DNA replication and FLAP endonuclease and the processing factor proliferating cell nuclear antigen.
• Further research implicates the supplementary role of proliferating cell nuclear antigen ( PCNA ) to DNA ligase I's function of joining Okazaki fragments.
• Most LMP2 research is focused on LMP2A Epstein-Barr nuclear antigen-2 responsiveness, and the ability to make LMP2B transcripts are conserved.
• This gene encodes a member of the HIN-200 ( hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats ) family of cytokines.
• These two specific gene mutations linked to the bowhead whale's ability to live longer are the ERCC1 gene and the proliferating cell nuclear antigen ( PCNA ) gene.
• This is because the FFAA mutation keeps FEN1 from interacting with PCNA ( proliferating cell nuclear antigen ), consequently not allowing it to complete its purpose during Okazaki fragment maturation.
• The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen ( PCNA ) and replication factor C ( RFC ).
• P21 can also interact with proliferating cell nuclear antigen ( PCNA ), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair.
• This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen.
• The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen ( PCNA ) and replication factor C ( RFC ).
• The spindle-shaped cells of the LAM lesion are more frequently proliferating cell nuclear antigen positive than the cuboidal cells, consistent with a proliferative phenotype . but not in adjacent normal lung tissue.
• DNMT1 is the most abundant methyltransferase in somatic cells, localizes to replication foci, has a 10 40-fold preference for hemimethylated DNA and interacts with the proliferating cell nuclear antigen ( PCNA ).
• The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis . 20-30 % of patients suffering from primary biliary cirrhosis have sp100 Abs.
• It has the following characteristics : VCAs ( Viral Capsid Antigen ) of the IgM class, antibodies to EBV early antigen ( anti-EA ), absent antibodies to EBV nuclear antigen ( anti-EBNA)
• PCNA is the proliferating cell nuclear antigen that serves as a DNA clamp that aids in the DNA polymerase activity ( DNA pol ) FEN1 ( Flap endonuclease 1 ) is then recruited to remove the overhanging 5'flap.